Research has shown that metolazone, a drug for hypertension, activates the mitochondrial repair mechanism in cells, helping to increase the body's lifespan.
Although aging is not a disease, scientistsThey are looking for drugs that can slow down this process and reduce its negative impact on health. One of the factors of aging is a decrease in the functionality of mitochondria, which serve as the energy stations of cells. The body has a mechanism for restoring these organelles, called the response.mitochondrial unfolded protein.
Researchers from Osaka City Universitystudied the effect of various drugs on stimulating this process. In tests on several species of worms, the scientists found that metolazone significantly increased their lifespan, outperforming the approximately 3,000 other drugs tested.
They found that the drug against hypertension, ohknown for over 50 years, has a strong effect on the HSP-6 gene (known as HSPA9 in humans), which is involved in activating the mitochondrial unfolded protein response.
Subsequent experiments with individualgroups of human cells also showed increased gene expression. As a result, the team hypothesized that the anti-aging effects of metolazone may also be present in mammals.
Although more research is needed totests of the drug's effect on longevity, but this cheap and well-known drug has performed far better than all approved anti-aging drugs.
Let us remember that scientists recently turned sugar molecules into a universal antiviral drug.
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